Biophysics in drug discovery: impact, challenges and opportunities

17 August 2016

Renaud JP, Chung C-w, Danielson UH, Egner U, Hennig M, Hubbard RE & Nar H (2016) Nature Reviews Drug Discovery, 15:679–698, doi:10.1038/nrd.2016.123

Over the past 25 years, biophysical technologies such as X‑ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermaltitration calorimetry have become key components of drug discovery platforms in many pharmaceutical companies and academic laboratories. There have been great improvements in the speed, sensitivity and range of possible measurements, providing high-resolution mechanistic, kinetic, thermodynamic and structural information on compound–target interactions. This Review provides a framework to understand this evolution by describing the key biophysical methods, the information they can provide and the ways in which they can be applied at different stages of the drug discovery process. We also discuss the challenges for current technologies and future opportunities to use biophysical methods to solve drug discovery problems.


More publications

 

Stay Updated

Sign up for the Beactica newsletter to receive our latest news and updates

This website uses cookies to improve your user experience. By continuing to browse this site, you agree to our use of cookies. More information. Ok!