Collaborating to open up new frontiers in human health
Beactica participates selectively in major international research initiatives. This enables the Company to be an active part in opening up new frontiers in the field of human health as well as train the next generation of drug hunters - both essential to the future of the sector and Beactica’s growth.
Beactica Therapeutics participates in a Marie Curie Innovative Training Network (ITN) called UbiMotif. The ITN is funded with EUR 4.1 million under the European Commission's Horizon 2020 programme and aims to deliver 15 skilled early-stage researchers in the area of targeted protein degradation, an emerging field predicted to revolutionize how “undruggable” proteins can be targeted in diseases such as cancer and neurodegeneration.
UbiMotif focuses on the identification, characterization and exploitation of certain motifs in the ubiquitin enzyme system that can target disease proteins for destruction, using the cell’s own garbage disposal system to degrade the protein. Pioneering early clinical data presented in 2019 showed that targeted protein degradation has the potential to create safe and well tolerated orally bioavailable drugs, so called proteolysis-targeting chimeras (PROTACs). Beactica has developed its own PROTACs-enabling technology to broaden its pipeline of first-in-class therapeutics.
UbiMotif consists of nine academic beneficiaries (Copenhagen University, Institute of Molecular Biology Mainz, ETH Zürich, Uppsala University, Hebrew University of Jerusalem, Institute of Cancer Research ICR, Sapienza University of Rome, University of Dundee and University of Tartu) and two industrial beneficiaries (Beactica Therapeutics and GlaxoSmithKline). The project starts officially on 1 December 2019 and will run for four years.
Beactica participates in this initial training network (ITN) that aims to deliver 15 skilled early-stage researchers in the field of fragment-based lead discovery (FBLD). The FRAGNET network is composed of eight academic beneficiaries (VU University Amsterdam, University of York, Hungarian Academy of Sciences, Universitat de Barcelona), four industrial beneficiaries (Beactica, Novartis, Vernalis, Zobio) as well as five partner organizations (GSK, Roche, Servier, IOTA, 24 Media Labs). The FRAGNET project is active 2016–2019.
Beactica participates in this European research initiative to create a large drug discovery platform with the aim to identify novel gram negative antibacterial substances. The ENABLE project is active 2014–2020.
Beactica participated in this European expertise network that aimed at molecular analysis and dynamic modeling of synapse function. The perspective was to generate a blueprint for the discovery of novel pathways and targets that enable rational strategies to design therapies for human brain disease. The SynSys project was active 2010–2014.
Beactica participated in this initial training network, ITN, that built on our knowledge of genome information and that aims to develop a new generation of neuroscientists, contributing to the fight against brain disorders. The BrainTrain project was active 2011–2014.
Beactica participated in this collaborative large-scale integrating project with a role to discover new classes of drugs targetting Cys-loop receptors, a superfamily of ligand-gated ion channels. The NeuroCyprres project was active 2008–2012.