Geitmann, M., Unge, T. and Danielson, U.H.(2006) J. Med. Chem. 49(8): 2375 – 2387.
Details of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors (NNRTIs) have been elucidated using a biosensor-based approach. This initial study was performed with HIV-1 reverse transcriptase... [...]
Cimitan, S., Lindgren, M., Bertucci, C. and Danielson, U.H. (2005) J. Medicinal Chemistry 48(10):3536-46.
The interactions of a set of compounds of potential importance for anticancer and AIDS chemotherapy with lipid membranes and plasma proteins were studied with a surface plasmon
resonance (SPR)... [...]
Shuman, C.F., Vrang, L. and Danielson, U.H.(2004) J. Medicinal Chemistry, 47(24):5953-61.
Despite the availability of large amounts of data for HIV-protease inhibitors and their effectiveness with wild type and resistant enzyme, there is limited knowledge about how this and other information can be... [...]
Geitmann, M. and Danielson, U.H. (2004) Analytical Biochemistry, 332(2), 203-14.
The interaction between human cytomegalovirus (HCMV) protease and a peptide substrate was studied using a surface plasmon resonance (SPR)-based biosensor. Immobilization of the enzyme to the sensor chip surface by amine... [...]
Poliakov, A., Johansson, A., Åkerblom, E., Oscarsson, K., Samuelsson, B., Hallberg, A., and Danielson, U.H. (2004) Biochimica Biophysica Acta 1672:51-59
The selectivity of hepatitis C virus (HCV) non-structural protein 3 (NS3) protease inhibitors was determined by evaluating their inhibitory effect... [...]
Shuman, C F. Hämäläinen, M. Danielson, U H.(2004) J. Molecular Recognition, 17, 106-119.
Interaction kinetic and thermodynamic analyses provide information beyond that obtained in general inhibition studies, and may contribute to the design of improved inhibitors and increased understanding of molecular... [...]
Gossas, T. and Danielson, U.H. (2003) J.Mol. Recogn., 16, 203-212.
The kinetic constants for the interactions between HIV-1 protease and a selection of inhibitors were determined at different pH-values using a biosensor based interaction assay. Since this technique does not involve a substrate, it was... [...]
Backman, D. and Danielson, U.H. (2003) Biochimica et Biophysica Acta 1646, 184-195.
In order to elucidate the characteristics of different aspartic proteases (Sap) secreted by Candida albicans, the kinetics of the interaction (k(on), k(off)) between Sap1 and Sap2 with acetyl-pepstatin and pepstatin... [...]
Markgren, P.-O. , Schaal., W., Hämäläinen, M., Karlén, A., Hallberg, A., Samuelsson, B. and Danielson, U.H.(2002) J. Med. Chem. 45(25), 5430-5439.
The interaction between HIV-1 protease and 58 structurally diverse transition-state analogue inhibitors has been analyzed by a surface plasmon resonance... [...]
Sönksen, C.P., Markgren, P.-O., Hämäläinen, M., Jansson, Ö., Danielson, U.H. and Roepstorff, P. (2001) European Journal of Mass Spectrometry 7, 385-391.
The combination of surface plasmon resonance (SPR) and mass spectrometry (MS) has created a unique approach to protein investigations. Surface plasmon... [...]