Danielson, U.H. (2009) Curr. Top. Med. Chem. 9: 1725-1735
The transition from high throughput screening of collections of drug-like compounds to screening of fragment libraries via lower throughput methods with high sensitivity has revolutionized early drug discovery. It is highlighting the need for... [...]
Danielson, U.H. (2009) Future Med. Chem. 1(8): 1399-1414.
Surface plasmon resonance biosensor technology has come of age and become an important tool for drug discovery. It is a label-free biophysical technique for the kinetic analysis of molecular interactions that provides exceptionally information-rich... [...]
Simister, P., Schmitt, M., Geitmann, M., Wicht, O., Danielson, U.H., Klein, R., Bressanelli, S. and Lohmann, V.(2009) J. Virol. , 83(22) 11926-11939.
The hepatitis C virus (HCV) isolate JFH1 represents the only cloned wild-type sequence capable of efficient replication in cell culture, as well as in... [...]
Wang, X., Hu, B., Zieba, A., Neumann, N., Kasper-Sonnenberg, M., Honsbein, A., Hultqvist, G., Conze, T., Witt, W., Geitmann, M., Danielson, H., Kolarow, R., Niemann, G., Lessmann, V. and Kilimann, M.(2009) Journal of Neuroscience 29 (40):12584-96.
Multidomain scaffolding proteins organize the molecular... [...]
Christopeit, T., Gossas, T., and Danielson, U.H.(2009) Anal. Biochem., 391(1), 2009, 39-44.
The interactions between Ca2+ and C-reactive protein (CRP) have been characterized using a surface plasmon resonance (SPR) biosensor. The protein was immobilized on a sensor chip, and increasing concentrations... [...]
Elinder, M., Nordström, H. Geitmann, M., Hämäläinen, M., Vrang, L., Öberg, B. and Danielson, U.H.(2009) J. Biomol. Screen. 14: 395 – 403.
A lead optimization library consisting of 800 HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) was screened in parallel against 4 clinically relevant... [...]
Nordström, H.; Gossas, T.; Hämäläinen, M.; Källblad, P.; Nyström, S.; Wallberg, H.; Danielson, U. H. (2008) J. Med. Chem.; (Article); 2008; 51(12); 3449-3459.
Small inhibitors of matrix metalloproteinase 12 (MMP-12) have been identified with a biosensor-based screening strategy and a specifically designed... [...]
Geitmann, M. and Danielson, U.H. (2007) Bioorg. Med. Chem. 15; 7344-54.
The thermodynamics of the interaction between mutant HIV-1 reverse transcriptase (K103N and Y181C) and a non-nucleoside reverse transcriptase inhibitor (NNRTI), the phenylethylthiazolylurea compound MIV-150, was obtained by determining... [...]
Norgren, A.S., Geitmann, M., Danielson, U.H., Arvidsson, P.I. (2007) J. Molecular Recognition 20: 132-138
The molecular recognition of a novel kind of hybrid conjugates, composed of artificial biomimetic β-peptide oligomers with an O-linked natural N-acetyl-galactosamine (the Tn-antigen) residue,... [...]
Geitmann, M., Unge, T. and Danielson, U.H.(2006) J. Med. Chem. 49(8): 2375 – 2387.
To decipher the mechanism for non-nucleoside inhibitor resistance of HIV-1 reverse transcriptase, the kinetics of the interaction between wild type and drug-resistant variants of the enzyme and structurally diverse inhibitors... [...]