Geitmann, M., Elinder, M., Seeger, C., Brandt, P., de Esch, I. and Danielson, U.H. (2011) J. Med. Chem. 54(3); 699-708.
A novel scaffold inhibiting wild type and drug resistant variants of human immunodeficiency virus type 1 reverse transcriptase (HIV-1RT) has been identified in a library consisting... [...]
Svahn, S., Vrang, L., Terelius, Y., Danielson, U.H. (2011) Anal. Biochem. 409; 163–175.
To develop efficient and reliable methods for prediction of serum protein binding of drug leads, the kinetic characteristics for the interactions between selected compounds and human serum albumin and α₁-acid... [...]
Geitmann, M., Dahl, G., Danielson, U.H.(2011) J. Mol. Recog. 24(1):60-70.
The mechanism and kinetics of the interactions between ligands and immobilized full-length hepatitis C virus (HCV) genotype 1a NS3 have been characterized by SPR biosensor technology. The NS3 interactions for a series of NS3 protease... [...]
Elinder, M., Geitmann, M., Gossas, T., Källblad, P., Winquist, J., Nordström, H., Hämäläinen, M. and Danielson, U.H.(2011) J. Biomol.Screen. 16(1); 15-25.
A new fragment library for lead discovery has been designed and experimentally validated for use in surface plasmon resonance (SPR) biosensor-based... [...]
De Kloe, G., Retra, K., Geitmann, M., Källblad, P., Nahar, T., van Elk, R., Smit, A.B., van Muijlwijk-Koezen, J.E., Leurs, R., Irth, H., Danielson, U.H. and de Esch, I.J.P. (2010) Journal of Medicinal Chemistry 53; 7192–7201.
The soluble acetylcholine binding protein (AChBP) is a homologue of the ligand-binding... [...]
Geitmann, M., Retra, K., de Kloe, G., Homan, E., Källblad, P., de Esch, I., and Danielson, U.H. (2010) Biochemistry 49; 8143–8154.
The mechanism of agonist interactions with Cys-loop ligand-gated ion channels has been studied using the acetylcholine-binding protein (AChBP) from Lymnaea stagnalis as... [...]
Domínguez, J.L., Christopeit, T., Villaverde, M.C., Gossas, T., Otero, J.M., Nyström, S., Baraznenok, V., Lindström, E., Danielson, U.H., Sussman, F.(2010) Biochemistry 49:7255–7263.
BACE-1 is one of the aspartic proteases involved in the cleavage of beta amyloid peptide, an initial step in the formation... [...]
Elinder, M., Selhorst, P., Vanham, G., Öberg, B., Vrang, L. and Danielson, U.H. (2010) Biochem. Pharmacol. 80;1133-1140
The importance of slow dissociation of non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral effect has been investigated. The kinetic characteristics of a series... [...]
Retra, K., Geitmann, M., Kool, J., Smit, G., de Esch, I.J.P., Danielson, U.H. and Irth, H.(2010) Anal. Biochem. 2010; 407; 58–64.
Surface plasmon resonance (SPR) biosensors recently gained an important place in drug discovery. Here we present a primary and secondary SPR biosensor screening methodology.... [...]
Lundquist, A., Hansen, S.B., Nordström, H., Danielson, U.H., Edwards, K.(2010) Anal. Biochem. 405; 153-159
The aim of this study was to investigate the potential of polyethylene glycol (PEG)-stabilized lipid bilayer disks as model membranes for surface plasmon resonance (SPR)-based biosensor analyses.... [...]