Publications

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

(2013) Med. Chem. Commun. , 4 (2), 432 - 442. Thomas Gossas , Helena Nordström, Ming-Hua Xu, Zhi-Hua Sun, Guo-Qiang Lin, Hans Wallberg and U. Helena Danielson. Med. Chem. Commun. , 2013, 4(2),432-442 Abstract The kinetic characteristics of hydroxamate-based inhibitors of matrix metalloproteinase (MMP)-12 were... [...]

Structural basis of ligand recognition in 5-HT3 receptors

(2013) EMBO reports , Jan. 3;14(1). Divya Kesters, Andrew J. Thompson, Marijke Brams, Rene´ van Elk, Radovan Spurny, Matthis Geitmann , Jose M. Villalgordo, Albert Guskov, U. Helena Danielson , Sarah C. R. Lummis, August B. Smit and Chris Ulens (2013), EMBO reports, Jan 3;14(1) Abstract The 5-HT3 receptor is... [...]

Aliskiren displays long-lasting interactions with human renin

(2012) N-S Arch.Pharmaco . 385(2);219-24 Gossas T , Vrang L, Henderson I, Sedig S, Sahlberg C, Lindström E, Danielson U. H. (2012) N-S Arch. Pharmaco. 385(2);219-24 Abstract Aliskiren is a selective renin inhibitor recently approved for use in hypertension. Efficacy duration appears longer than what would... [...]