Korn M, Wohlfart P, Gossas T , Kullman-Magnusson M , Niederhaus B, Dedio J, Tennagels N. (2019) Regul. Toxicol. Pharmacol., 109:104497. [Epub ahead of print] Abstract SAR342434 is a biosimilar of insulin lispro (Humalog® U-100). Batches of SAR342434 were compared with Humalog® batches of either EU or US origin in... [...]
Pandya NJ, Seeger C , Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson UH , Li KW, Heine M, Spijker S, Frischknecht R, Smit AB (2018) Cell Reports, 24:1218−1230. Abstract Lateral diffusion on the neuronal plasma membrane of the AMPA-type glutamate receptor (AMPAR) serves... [...]
Mould DP, Alli C, Bremberg U, Cartic S, Jordan AM, Geitmann M, Maiques-Diaz A, McGonagle AE, Somervaille TCP, Spencer GJ, Turlais F, Ogilvie D. (2017) J Med Chem., 60:7984−7999.AbstractInhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation of leukemia stem cells in acute myeloid... [...]
Mould DP, Bremberg U, Jordan AM, Geitmann M, McGonagle AE, Somervaille TCP, Spencer GJ, Ogilvie DJ. (2017) Bioorg Med Chem Lett., 27:4755–4759.AbstractAs part of our ongoing efforts to develop reversible inhibitors of LSD1, we identified a series of 4-(pyrrolidin-3-yl)benzonitrile derivatives that act as successful scaffold-hops... [...]
Paulus Wohlfart, Thomas Gossas, Maria Lindgren, Mari Kullman-Magnusson, and Norbert Tennagels (2017) Poster at International Symposium on Insulin Receptor and Insulin Action IR2017 in Nice, France.Summary In summary, we have developed a novel SPR biosensor-based assay, which allows the kinetic measurement of insulin... [...]
Mould DP, Bremberg U, Jordan AM, Geitmann M, Maiques-Diaz A, McGonagle AE, Small HF, Somervaille TCP, Ogilvie D. (2017) Bioorg Med Chem Lett., 27:3190–3195.AbstractA series of reversible inhibitors of lysine specific demethylase 1 (LSD1) with a 5-hydroxypyrazole scaffold have been developed from compound 7, which was identified... [...]
Renaud JP, Chung C-w, Danielson UH, Egner U, Hennig M, Hubbard RE & Nar H (2016) Nature Reviews Drug Discovery, 15:679–698, doi:10.1038/nrd.2016.123AbstractOver the past 25 years, biophysical technologies such as X‑ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy... [...]
Elizabeth Anscombe, Elisa Meschini, Regina Mora-Vidal, Mathew P. Martin, David Staunton, Matthis Geitmann, U. Helena Danielson, Will A. Stanley, Lan Z. Wang, Tristan Reuillon, Bernard T. Golding, Celine Cano, David R. Newell, Martin E.M. Noble, Stephen R. Wedge, Jane A. Endicott and Roger J. Griffin (2015) Chemistry & Biology 22:1–6.Summary Irreversible... [...]
Spurny R, Debaveye S, Farinha A, Veys K, Vos A.M, Gossas T, Atack J, Bertrand S, Danielson UH, Tresadern G, Ulens C. (2015) PNAS, 112:E2543–52.AbstractThe α7 nicotinic acetylcholine receptor (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synaptic signaling. In this study,... [...]
Winquist J, Geschwindner S, Xue Y, Gustavsson L, Musil D, Deinum J, Danielson UH. (2013) Biochemistry, Jan 29;52(4):613-26
Abstract
To improve our understanding of drug-target interactions, we explored the effect of introducing substituted amine residues with increased chain length in the P3 residue of... [...]