Markgren, P.-O., Lindgren, M.T., Gertow, K., Karlsson, R., Hämäläinen, M.D. and Danielson, U.H. (2001) Analytical Biochemistry 291, 207-218.
The interaction between HIV-1 protease and inhibitors has been studied with optical biosensor technology. Optimized experimental procedures and mathematical analysis... [...]
Alterman, M., Sjöbom, H., Säfsten, P., Markgren, P.-O., Danielson, U.H., Hämäläinen, M., Löfås, S., Hultén, J., Classon, B., Samuelsson, B. and Hallberg, A. (2001) European Journal of Pharmaceutical Sciences 13(2), 203-212.
The commonly used HIV-1 protease assays rely on measurements of the effect... [...]
Hämäläinen, M.D., Markgren, P.-O., Schaal, W., Karlén, A., Classon, B., Vrang, L. Samuelsson, B., Hallberg, A. and Danielson, U.H. (2000) Journal of Biomolecular Screening 5(5), 353-359.
The interaction between 290 structurally diverse human immunodeficiency virus type 1 (HIV-1) protease inhibitors... [...]
Markgren, P.-O., Hämäläinen, M. and Danielson, U.H.(2000) Analytical Biochemistry 279, 71-78.
The interaction between HIV-1 protease and reversible inhibitors was studied by surface plasmon resonance biosensor technology. The steady-state binding level and the time course of association and dissociation... [...]
Markgren, P.-O., Hämäläinen, M. and Danielson, U.H. (1998) Analytical Biochemistry 265, 340-350.
A high-resolution optical biosensor assay for screening of low-molecular-weight compounds, using an immobilized protein target, has been developed. HIV-1 proteinase was immobilized on the sensor surface... [...]
Shuman, C.F., Markgren, P.-O., Hämäläinen, M. and Danielson, U.H.(2003) Antiviral Research, 58, 235-242.
The kinetics of the interaction between drug-resistant variants of HIV-1 protease (G48V, V82A, L90M, I84V/L90M, and G48V/V82A/I84V/L90M) and clinically used inhibitors (amprenavir, indinavir, nelfinavir,... [...]