Publications

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

De Kloe, G., Retra, K., Geitmann, M., Källblad, P., Nahar, T., van Elk, R., Smit, A.B., van Muijlwijk-Koezen, J.E., Leurs, R., Irth, H., Danielson, U.H. and de Esch, I.J.P. (2010) Journal of Medicinal Chemistry 53; 7192–7201. Abstract The soluble acetylcholine binding protein (AChBP) is a homologue of the ligand-binding... [...]

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Lundquist, A., Hansen, S.B., Nordström, H., Danielson, U.H., Edwards, K.(2010) Anal. Biochem. 405; 153-159 Abstract The aim of this study was to investigate the potential of polyethylene glycol (PEG)-stabilized lipid bilayer disks as model membranes for surface plasmon resonance (SPR)-based biosensor analyses.... [...]

Fragment library screening and lead characterization using SPR biosensors

Danielson, U.H. (2009) Curr. Top. Med. Chem. 9: 1725-1735 Abstract The transition from high throughput screening of collections of drug-like compounds to screening of fragment libraries via lower throughput methods with high sensitivity has revolutionized early drug discovery. It is highlighting the need for... [...]