Divya Kesters, Andrew J. Thompson, Marijke Brams, Rene´ van Elk, Radovan Spurny, Matthis Geitmann, Jose M. Villalgordo, Albert Guskov, U. Helena Danielson, Sarah C. R. Lummis, August B. Smit and Chris Ulens (2013), EMBO reports, Jan 3;14(1)
The 5-HT3 receptor is a pentameric serotonin-gated ion channel,... [...]
Solca F, Dahl G, Zoephel A, Bader G, Sanderson M, Klein C, Kraemer O, Himmelsbach F, Haaksma E, Adolf GR. (2012) J. Pharmacol. Exp.Ther. 343(2):342-50
Deregulation of the ErbB receptor network is well recognized as an oncogenic driver in epithelial cancers. Several targeted drugs have been developed,... [...]
Seeger C, Gorny X, Reddy PP, Seidenbecher C, Danielson UH. J Mol Recognit. 2012 Oct;25(10):495-503.
The kinetic and mechanistic details of the interaction between caldendrin, calmodulin and the B-domain of AKAP79 were determined using a biosensor-based approach. Caldendrin was found to compete with... [...]
Seeger C, Christopeit T, Fuchs K, Grote K, Sieghart W, Danielson UH. (2012) Biochem Pharmacol, 84(3);341-51
A surface plasmon resonance biosensor assay was established for studying the interactions of 51 histaminergic and 15 GABAergic ligands with homo-oligomeric β3 GABA(A) receptors. Detergent... [...]
Gossas T, Vrang L, Henderson I, Sedig S, Sahlberg C, Lindström E, Danielson U. H. (2012) N-S Arch. Pharmaco. 385(2);219-24
Aliskiren is a selective renin inhibitor recently approved for use in hypertension. Efficacy duration appears longer than what would be expected based on its circulating half-life.... [...]
Domínguez JL, Gossas T, Carmen Villaverde M, Helena Danielson U, Sussman F.(2012) Biorg. Med. Chem. Aug1; 20 (15):4838-47.
The pH dependence of the HIV-1 protease inhibitor affinity was studied by determining the interaction kinetics of a series of inhibitors at three pH values by surface plasmon... [...]
Christopeit, T., Stenberg, G., Gossas, T., Nyström., S., Baraznenok, V., Lindström, E., Danielson, U.H. (2011) Analytical. Biochem. 414; 14-22.
A surface plasmon resonance (SPR) biosensor-based assay for membrane-embedded full-length BACE1 (β-site amyloid precursor protein cleaving enzyme 1), a... [...]
Tegler, L.T. Nonglaton, G., Büttner, F., Caldwell, K., Christopeit, T., Danielson, U.H., Fromell, K., Gossas, T., Larsson, A., Longati, P., Norberg, T., Ramapanicker, R., Rydberg, J. and Baltzer. (2011) Angew. Chem. 50; 1823-1827.
High-affinity binders for the C-reactive protein (CRP), with dissociation... [...]
Brandt, P., Geitmann, M. and Danielson, U.H. (2011) J. Med. Chem. 54(3); 709-718.
This study has taken a closer look at the theoretical basis for protein−fragment interactions. The approach involved the deconstruction of 3 non-nucleoside inhibitors of HIV-1 reverse transcriptase and investigation... [...]
Geitmann, M., Elinder, M., Seeger, C., Brandt, P., de Esch, I. and Danielson, U.H. (2011) J. Med. Chem. 54(3); 699-708.
A novel scaffold inhibiting wild type and drug resistant variants of human immunodeficiency virus type 1 reverse transcriptase (HIV-1RT) has been identified in a library consisting... [...]