Measuring the kinetic interaction of insulin analogs with solubilized full-length insulin receptors

Paulus Wohlfart, Thomas Gossas, Maria Lindgren, Mari Kullman-Magnusson, and Norbert Tennagels (2017) Poster at International Symposium on Insulin Receptor and Insulin Action IR2017 in Nice, France.


In summary, we have developed a novel SPR biosensor-based assay, which allows the kinetic measurement of insulin to its two binding sites on the full-length insulin receptor. The methodology may be useful for the characterization of the different binding properties of insulin analogs and other ligand mimetic.

Link to the poster