Beactica Software

- Uncompromised Decisions For Accelerated Drug Discovery

Benefits

Beactica’s proprietary software provides an unrivalled decision tool for the evaluation of SPR biosensor-based dose-response data. The software is designed to distinguish unspecific signals from real binding events. It is also ideally suited for understanding and exploiting data from targets lacking positive controls.

Key Features

  • Generates state-of-the-art determination of fragment affinities
  • Enables quantification of the degree of specificity of the dose-response signals

Technical Details

By accounting for the non-specific components in the dose-response signals, differences in MW and refractive index increment between ligands, and changes in surface activity during an experiment, state-of-the-art KD values can be determined. This is accomplished through unique algorithms proprietary to Beactica.

Sprint Software_C.Note_107_s_150dpi

The software screen shot above shows a set of fragment hits followed up by a dose-response experiment. Secondary interactions/non-specific signals are extracted as a linear dose-response component whereas the specific component is illustrated by the dashed line.